Physical Dependence and Plasma Concentrations of Morphine in Rats
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چکیده
منابع مشابه
Olive (Olea europaea L.) leaf extract and its main component (oleuropein) mitigate the development of morphine physical dependence in rats
Introduction: Recently, it has been demonstrated that olive leaf extract and its main component have calcium channel blocker, anti-inflammatory and anti-oxidative properties. However, the effects of olive leaf extract on opioid dependence have not yet been clarified. Methods: To develop morphine dependence, morphine was injected twice daily for 7 days according to an escalating dose in rats...
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Objective(s):Dependence and tolerance to opioid analgesics are major problems limiting their clinical application. a-Terpineol is a monoterpenoid alcohol with neuroprotective effects which is found in several medicinal plants such as Myrtus communis, Laurus nobilis, and Stachys byzantina. It has been shown that some of these medicinal plants such as S. byzantina attenuate dependence and toleran...
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Concentrations of morphine, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G) were measured by h.p.l.c. in plasma and cerebrospinal fluid (CSF) samples from 16 patients with cancer receiving oral (controlled-release) morphine. There was a close correlation between plasma and CSF morphine concentrations (r = 0.94, P = 0.0001) and both correlated with drug dosage (r = 0.61, P = 0.013 ...
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This study investigated the effect of delta opioid receptor blockade by naltrindole on the development of physical dependence and tolerance to the antinociceptive and respiratory depressive effects of morphine in rats. Chronic morphine was delivered either by s.c. injection of increasing amounts of morphine over 5 days or by s.c. implantation of morphine pellets. Animals were cotreated with sal...
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Background: Chronic administration of morphine cause physical dependence but the exact mechanism of this phenomenon remains unclear. The aim of this study is the assessment of systemic and intracerebroventricular (icv) administration of ramelteon (a melatonin receptor agonist) on morphine physical dependence. Methods: 88 adult male rats were divided into 2 major groups, namely “systematic” and ...
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ژورنال
عنوان ژورنال: Journal of Drug Abuse
سال: 2016
ISSN: 2471-853X
DOI: 10.21767/2471-853x.100032